You want an even capacity of fans drawing air in and blowing air out. IE same size fans to draw air in and blow it out. In general you want slightly more drawing in than blowing out. - For a multi level home you generally want all of the fans on a lower level to draw air in and all of the fans on the upper level to blow air out. This will assist in the natural convection process.
Also, it should go without saying, but don't close any doors in any rooms that have fans if you can help it.
What the educator does in teaching is to make it possible for the students to become themselves.-Paulo Freire